A novel VCP modulator, KUS121, attenuates atherosclerosis progression by maintaining intracellular ATP and mitigating ER stress in endothelial cells
Fuquan Zou, Osamu Baba, Takahiro Horie, Yasuhiro Nakashima, Shuhei Tsuji, Tomohiro Yamasaki, Chiharu Otani, Sijia Xu, Miyako Imanaka, Kazuki Matsushita, Keita Suzuki, Eitaro Kume, Hidenori Kojima, Qiuxian Qian, Kayo Kimura, , Koh Ono
This study shows that KUS121 reduces atherosclerosis by maintaining ATP levels and reducing ER stress in endothelial cells.
Atherosclerosis · May 1, 2025Peer-reviewedPathology