Reverse engineering Lewy bodies suggests alpha-synuclein pathology as condensatopathy
Roberto Sansevrino, Александр Коробейников, Jianhua Chen, Christian Hoffmann, Hugo Le Roy, Kiersten M. Ruff, András Major, Asima Nayak, Paula Brosius, Axel A. Ekman, Shujin He, Michael Chen, Joshua Jackson, Gerard Aguilar Pérez, Han Wang, , Dragomir Milovanović
The paper shows that alpha-synuclein phase separation can form Lewy body-like structures without pre-existing seeds, suggesting a new mechanism for neurodegeneration.
bioRxiv · Oct 15, 2026 · PreprintNeuroscience