Carolyn A. Larabell

Reverse engineering Lewy bodies suggests alpha-synuclein pathology as condensatopathy

The paper shows that alpha-synuclein phase separation can form Lewy body-like structures without pre-existing seeds, suggesting a new mechanism for neurodegeneration.

A 3D Soft X-Ray Structural Atlas of Multicellular Cable Bacteria

This study creates a 3D structural atlas of cable bacteria using SXT and other techniques, revealing intracellular organization and conductive network features.

Nucleus softens during herpesvirus infection

This study shows that the nucleus softens during herpesvirus infection due to reduced outward forces and low biomolecular density in the viral replication compartment.

Decoding acute neuroinflammatory states from the 3D architecture of in vitro microglia

The paper decodes acute neuroinflammatory states in mouse microglia by analyzing their 3D cellular architecture and links lipid-endosome reorganization to the mTORC1 pathway.

Interior soft x-ray tomography with sparse global sampling

This paper develops a sparse reconstruction algorithm for soft X-ray tomography to achieve high spatial resolution and whole-cell imaging with reduced radiation dose.

Automated segmentation of soft X-ray tomography: native cellular structure with sub-micron resolution at high throughput for whole-cell quantitative imaging in yeast

This paper introduces an auto-segmentation pipeline for soft X-ray tomography to enable high-throughput, precise 3D morphometric analysis of yeast cells and organelles.

Soft X-ray tomography reveals variations in B.subtilis biofilm structure upon tasA deletion

This paper uses soft X-ray tomography to analyze B.subtilis biofilm structure, showing structural changes in a tasA deletion mutant and the effect of TasA protein addition.

Ensemble and Iterative Engineering for Maximized Bioconversion to the Blue Pigment, Indigoidine from Non-Canonical Sustainable Carbon Sources

The paper develops growth-coupled microbial strains for high-yield indigoidine production using iterative engineering and computational evaluation.