Hypoxia reduces induced LRIG1 protein despite sustained mRNA induction in colorectal cancer organoids
Akari Minamiura, Shuto Aoki, Rio Matsuwaka, Arisa Yoshimoto, Yumi Nobori, T. Matsuura, Shinji Takamatsu, Eiji Miyoshi, Jumpei Kondo
This study shows hypoxia reduces LRIG1 protein levels in colorectal cancer organoids despite increased mRNA, suggesting limitations in LRIG1-based cancer therapies under hypoxic conditions.
bioRxiv · Oct 20, 2026 · PreprintBiochemistry