Jumpei Kondo

Hypoxia reduces induced LRIG1 protein despite sustained mRNA induction in colorectal cancer organoids

This study shows hypoxia reduces LRIG1 protein levels in colorectal cancer organoids despite increased mRNA, suggesting limitations in LRIG1-based cancer therapies under hypoxic conditions.

Prohaptoglobin Promotes Pancreatic Cancer Progression by sustaining YAP Activity

This paper shows prohaptoglobin promotes pancreatic cancer by sustaining YAP activity, enabling cells to bypass contact inhibition and enhance motility and tumor growth.

Enterococcus faecalis is involved in the progression of the early stages of latent chronic pancreatitis surrounding pancreatic cancer tissue

The paper investigates the role of Enterococcus faecalis in the progression of latent chronic pancreatitis associated with pancreatic cancer tissue through pathological and serological analyses.

IGF2BP3 is essential for the growth heterogeneity of colorectal adenoma cells by regulating MYC

The paper identifies IGF2BP3 as a regulator of MYC that contributes to growth heterogeneity in colorectal adenoma cells through both transcriptional and translational mechanisms.

FUT8 mediated core fucosylation modulates growth related functions of LRP1 in liver cancer cells

This study identifies LRP1 as a core-fucosylated protein regulated by FUT8 in liver cancer, showing its role in cell proliferation and signaling.

Functional Impact of Glycosylation and Splicing Variants of LRIG1 on EGFR Proteostasis in Cancer

The paper investigates how glycosylation and splicing variants of LRIG1 affect EGFR proteostasis in cancer, finding that N74Q mutation and exon 2 skipping enhance LRIG1-EGFR binding and degradation.

ASURAT: functional annotation-driven unsupervised clustering of single-cell transcriptomes

ASURAT performs unsupervised clustering and functional annotation of single-cell transcriptomes, improving biological interpretability with fewer manual curations.