Author

Shuyi Zhang

University of Illinois Urbana-ChampaignPrimary ORCID profile (0000-0001-8500-5836 · 2 papers)Unclaimed ORCID profile · follow to get notified of new preprints

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Same name, identified by ORCID

Shuyi ZhangiD2 papers · Tsinghua University

Biology Disciplines

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Bioinformatics· 2 Physiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:CITE-seq· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:batch correction / integration· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1

Frequent Co-Authors

Jacob R. Leistico· 2 shared Jeffrey B. ChengiD· 2 shared Jun S. SongiD· 2 shared Raymond Jaihyun ChoiD· 2 shared Christopher P. CookiD· 1 shared Jiacheng Guo· 1 shared Mingyu LiiD· 1 shared Ning Chen· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersBioinformatics

Jacob R. Leistico

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Author profile →

3 papers

Recent·Most cited

Tirzepatide improves pancreatic β-cell function in mice and patients with type 2 diabetes.

Zhehui Li, Jiacheng Guo, Ying Cheng, Tongyu Zhang, Xiumei Luo, Shuyi Zhang, Qi Ren, Zhiqiang Wu, Ning Chen, Mingyu Li

This study shows tirzepatide improves β-cell function in T2D by reversing dedifferentiation and restoring transcription factors through FOXO1 reactivation.

bioRxiv · Feb 16, 2026 · PreprintPhysiology

Spectral clustering of single-cell multi-omics data on multilayer graphs

Shuyi Zhang, Jacob R. Leistico, Raymond Jaihyun Cho, Jeffrey B. Cheng, Jun S. Song

This paper introduces two spectral clustering algorithms for multi-omic single-cell data and shows they produce results comparable to Seurat's WNN method on a CITE-seq dataset.

Bioinformatics · Jun 2, 2022Peer-reviewedBioinformatics

Riemannian geometry and statistical modeling correct for batch effects and control false discoveries in single-cell surface protein count data from CITE-seq

Shuyi Zhang, Jacob R. Leistico, Christopher P. Cook, Yale Liu, Raymond Jaihyun Cho, Jeffrey B. Cheng, Jun S. Song

Physical review. E · Jul 27, 2020Peer-reviewedBioinformatics