Prolonged exposure to insulin causes epigenetic alteration leading to insulin resistance
Shehnaz Bano, Shyam More, Dattatray Mongad, Abdul Khalique, Dhiraj Prakash Dhotre, Manoj Kumar Bhat, Vasudevan Seshadri
The paper shows prolonged insulin exposure without glucose causes epigenetic changes leading to insulin resistance in cells and mice.
bioRxiv · Apr 28, 2022 · PreprintMolecular Biology