Manoj Kumar Bhat

Hypercholesterolemia-induced impairment in sorafenib functionality is overcome by avasimibe co-treatment

This study shows that avasimibe restores sorafenib's anticancer effect in hypercholesterolemia-induced hepatocellular carcinoma by enhancing cytotoxicity and reducing ERK signaling.

Obese serum factors aggravate DNA damage, alter DNA damage response, and promote proliferation in colon cancer cells

This study shows that obese serum increases DNA damage, reduces DNA repair, activates DDR pathways, and promotes colon cancer cell proliferation.

Metformin-Induced Mitochondrial Remodelling Creates Adaptive and Targetable Vulnerabilities in Cancer Cells

This study shows metformin induces mitochondrial remodeling in cancer cells, creating vulnerabilities that can be targeted to enhance its anticancer effects.

Prolonged exposure to insulin causes epigenetic alteration leading to insulin resistance

The paper shows prolonged insulin exposure without glucose causes epigenetic changes leading to insulin resistance in cells and mice.

PAN-INDIA 1000 SARS-CoV-2 RNA Genome Sequencing Reveals Important Insights into the Outbreak

The paper sequences 1000 SARS-CoV-2 genomes from India, revealing multiple circulating lineages, predominant A2a haplotype with D614G mutation, and geographic mutation clustering.

Phylogenomic analysis of SARS-CoV-2 genomes from western India reveals unique linked mutations

The paper analyzes SARS-CoV-2 genomes from western India, identifying unique linked mutations and their association with symptoms and age groups.