Glioblastoma model mouse rescue from mortality by brain-targeted catalytically-enhanced angiotensin-converting enzyme 2 mutant-antibody fusion protein
Pete Heinzelman, George R Nageeb, John Choi, Justin Liu, Si Yeon Lee, Philip A Romero, Michael Lim
The paper shows that combining ACE2dm-s1 with a STING agonist improves survival in GBM model mice, unlike losartan alone, and suggests ACE2dm-s1 modulates the tumor microenvironment.
bioRxiv · Nov 4, 2026 · PreprintCancer Biology