Enzyme-independent functions of HDAC3 in the adult heart
Sichong Qian, Chen Zhang, Wenbo Li, Shiyang Song, Guanqiao Lin, Zixiu Cheng, Wenjun Zhou, Huiqi Yin, Yueli Wang, Haiyang Li, Ying H. Shen, Zheng Sun
This study shows that HDAC3's cardioprotective role in adult hearts is independent of its enzymatic activity, as enzyme-inactive HDAC3 can rescue gene expression and cardiac function.
Acta Pharmaceutica Sinica B · May 10, 2025Peer-reviewedPhysiology