Author

Chen Zhang

Baylor College of MedicineORCID 0000-0002-3156-1391Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Chen Zhang7 papers · Capital Medical University

Biology Disciplines

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Immunology· 1 Pathology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Organism:mouse· 3 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Assay:scRNA-seq· 2 Assay:bulk RNA-seq· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

Ying H. SheniD· 3 shared Alan DaughertyiD· 2 shared Hong S. LuiD· 2 shared Scott A. LeMaireiD· 2 shared Yanming LiiD· 2 shared Abhijit ChakrabortyiD· 1 shared Bowen Li· 1 shared David B GrafiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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3 shared papersImmunology

Ying H. ShenORCID

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3 papers

Recent·Most cited

Epigenetic Programming of Macrophage Phenotypes by STING-IRF3 Drives Inflammation in Ascending Thoracic Aortic Dissection

Bowen Li, Chen Zhang, Samantha Xu, Yanming Li, Deborah C. Vela, Hernan G. Vasquez, Lin Zhang, Abhijit Chakraborty, Hong S. Lu, Joseph S. Coselli, Toru Suzuki, Alan Daugherty, Dianna M. Milewicz, Ziad Mallat, Liwu Li, , Ying H. Shen

This study identifies STING-IRF3-mediated epigenetic programming of macrophages as a driver of inflammation in aortic dissection, showing its role in pro-inflammatory bias and therapeutic potential.

bioRxiv · Jan 25, 2026 · PreprintImmunology

Enzyme-independent functions of HDAC3 in the adult heart

Sichong Qian, Chen Zhang, Wenbo Li, Shiyang Song, Guanqiao Lin, Zixiu Cheng, Wenjun Zhou, Huiqi Yin, Yueli Wang, Haiyang Li, Ying H. Shen, Zheng Sun

This study shows that HDAC3's cardioprotective role in adult hearts is independent of its enzymatic activity, as enzyme-inactive HDAC3 can rescue gene expression and cardiac function.

Acta Pharmaceutica Sinica B · May 10, 2025Peer-reviewedPhysiology

Smooth Muscle Cells and Fibroblasts in the Proximal Thoracic Aorta Exhibit Minor Differences Between Embryonic Origins in Angiotensin II-driven Transcriptional Alterations

Sohei Ito, David B Graf, Yuriko Katsumata, Jessica J. Moorleghen, Chen Zhang, Yanming Li, Scott A. LeMaire, Ying H. Shen, Hong S. Lu, Alan Daugherty, Hisashi Sawada

The paper examines transcriptomic changes in smooth muscle cells and fibroblasts from different embryonic origins in the proximal thoracic aorta under AngII infusion, finding modest differences between origins.

bioRxiv · Jan 23, 2025 · PreprintPathology