Author

Sigrid Nachtergaele

Primary ORCID profile (0000-0003-0231-580X · 2 papers)Unclaimed ORCID profile · follow to get notified of new preprints

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Sigrid NachtergaeleiD2 papers · Yale University

Biology Disciplines

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Developmental Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1

Frequent Co-Authors

Andreas Sagner· 1 shared Christian SieboldiD· 1 shared Douglas F Covey· 1 shared Eamon FX Byrne· 1 shared Giovanni Luchetti· 1 shared Jennifer H Kong· 1 shared Rajat RohatgiiD· 1 shared Ria Sircar· 1 shared

Activity by Year

2016-2016 · peak 1/yr

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8 top collaborators · 28 mutual co-author links

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1 shared paperDevelopmental Biology

Andreas Sagner

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1 paper

Recent·Most cited

Cholesterol activates the G-protein coupled receptor Smoothened to promote morphogenetic signaling

Giovanni Luchetti, Ria Sircar, Jennifer H Kong, Sigrid Nachtergaele, Andreas Sagner, Eamon FX Byrne, Douglas F Covey, Christian Siebold, Rajat Rohatgi

The paper shows cholesterol directly activates the GPCR Smoothened to drive Hedgehog signaling by binding its extracellular domain, independent of traditional GPCR mechanisms.

eLife · Oct 5, 2016Peer-reviewedDevelopmental Biology