Author
Centre for Human GeneticsORCID 0000-0002-6635-3621Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
Chris E. Williams, Laura Margaret Nocka, George Hedger…·Rajat Rohatgi
The paper describes the structure and function of a membrane-spanning E3 ubiquitin ligase complex, revealing its role in developmental processes and linking mutations to human birth defects.
Pragya Parashara, Lei Gao, Alyssa Riglos…·Jennifer H. Kong
This study identifies ATRN and ATRNL1 as transmembrane adapters that recruit MGRN1 to ubiquitinate and degrade MC1R and MC4R, expanding the known substrate repertoire of MGRN1.
Giovanni Luchetti, Ria Sircar, Jennifer H Kong…·Rajat Rohatgi
The paper shows cholesterol directly activates the GPCR Smoothened to drive Hedgehog signaling by binding its extracellular domain, independent of traditional GPCR mechanisms.