Fiber-type vulnerability and proteostasis reprogramming in skeletal muscle during pancreatic cancer cachexia
Bowen Xu, Aniket S. Joshi, Meiricris Tomaz da Silva, Silin Liu, Ashok Kumar
This study identifies molecular mechanisms of skeletal muscle wasting in pancreatic cancer cachexia using snRNA-seq and bulk RNA-seq, revealing transcription factor activity and potential therapeutic targets.
JCI Insight · Jan 27, 2026Peer-reviewedCell Biology