The BMP4-BMPR1A axis represses BRCA1 in mammary stem cells and contributes to tumor initiation.
Simon Aho, Marie Perbet, Isabelle Treilleux, Adrien Buisson, Sandrine Jeanpierre, E. Delay, Véronique Maguer‐Satta, Boris Guyot
This study identifies the BMP4-BMPR1A axis as a regulator of BRCA1 expression in mammary stem cells, contributing to tumor initiation and PARP inhibitor sensitivity in BLBC.
bioRxiv · Jun 27, 2025 · PreprintCancer Biology