Deep learning enables therapeutic antibody optimization in mammalian cells by deciphering high-dimensional protein sequence space
Derek M. Mason, Simon Friedensohn, Cédric R. Weber, Christian Jordi, Bastian Wagner, Simon M. Meng, Pablo Gaínza, Bruno E. Correia, Sai T. Reddy
Mammalian display of CRISPR-introduced trastuzumab mutant libraries trains a network that picks antigen binders out of a hundred-million-variant virtual library; 30 of 30 tested variants bound.
bioRxiv · Jun 2, 2019 · PreprintSynthetic Biology