Synthetic BiologybioRxivPreprint
Deep learning enables therapeutic antibody optimization in mammalian cells by deciphering high-dimensional protein sequence space
Derek M. Mason, Simon Friedensohn, Cédric R. Weber…·Sai T. Reddy
Mammalian display of CRISPR-introduced trastuzumab mutant libraries trains a network that picks antigen binders out of a hundred-million-variant virtual library; 30 of 30 tested variants bound.
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