Sensory neurons safeguard from mutational inheritance by controlling the CEP-1/p53-mediated DNA damage response in primordial germ cells
Simon Uszkoreit, David H. Meyer, Oded Rechavi, Björn Schumacher
The paper shows ASI sensory neurons control the CEP-1/p53 DNA damage response in PGCs via TGF-beta signaling, reducing inherited mutations.
bioRxiv · Jul 19, 2022 · PreprintGenetics