Hemodynamic Characteristics of Acute Hypersensitivity Reaction Induced by PEGylated Nanocomposite in Rats: Mechanism at the Nano-Bio Interface
Sin-Ting Ngo, Yun Cheng, Si–Yi Chen, Ming Sun, Jau‐Song Yu, Kun‐Yi Chien, Hsi-Mei Chen, Yunn‐Hwa Ma
This study investigates the hemodynamic effects of PEGylated nanocomposites in rats, finding that complement activation and microvascular occlusion contribute to acute hypersensitivity reactions.
bioRxiv · Mar 12, 2025 · PreprintPharmacology & Toxicology