Genetic Inactivation of Beta-Catenin Attenuates and Its Activation Aggravates Desmoplakin Cardiomyopathy
Melis Olcum, Siyang Fan, Leila Rouhi, Sirisha M. Cheedipudi, Benjamin Cathcart, Hyun-Hwan Jeong, Zhongming Zhao, Priyatansh Gurha, Ali J. Marian
This study shows that genetic inactivation of beta-catenin improves desmoplakin cardiomyopathy by restoring oxidative phosphorylation gene expression, while its activation worsens the condition.
bioRxiv · Mar 2, 2023 · PreprintGenetics