Neuronal microscale biophysical instability mediates macroscale network dynamics shaping pathological manifestations
Vipin Kumar, Victor M. Sanchez Franco, Faith S Ferry, Yizhou Xie, Anelise N Hutson, Yutian J. Zhang, Skylar D. Daniels, Dieu Linh Nguyen, Lucia K Spera, Eleanora M. Snyder, Anneke Knauss, Srilakshiya L. Sudhakar, Grace Y. Duan, Elizabeth M. Paul, Masashi Tabuchi
The paper identifies increased biophysical instability in spike initiation as a conserved feature across Drosophila and human neuronal models of neurological diseases.
bioRxiv · Apr 4, 2026 · PreprintNeuroscience