Increased CD33 levels tune activation and function of iinduced human microglial cells through inhibition of the TREM2 pathway
Amr Omer, Smita Jagtap, Elga Morrison, Lauren M. Carito, Alexander Lee Prinzen, Stefan I. McDonough, Benjamin J. Andreone
This study shows that CD33 modulates microglial function in Alzheimer's disease by inhibiting TREM2 activation, with reduced CD33 increasing amyloid beta uptake and TREM2 activity.
bioRxiv · Jan 30, 2026 · PreprintNeuroscience