Biochemical Impact of p300-Mediated Acetylation of Replication Protein A: Implications for DNA Metabolic Pathway Choice
Onyekachi E. Ononye, Sneha Surendran, Tripthi Battapadi, Pamela S. VanderVere-Carozza, Olivia Kay Howald, Athena K. Petrides, Matthew R. Jordan, Diana Ainembabazi, Marc S. Wold, John J. Turchi, Lata Balakrishnan
This study shows that p300-mediated acetylation of RPA enhances its ssDNA binding affinity, particularly during G1/S phase and UV damage, influencing DNA metabolic pathway choice.
Journal of Biological Chemistry · May 17, 2025Peer-reviewedBiochemistry