Structural Hijacking of FcRn by Human Astrovirus Spikes Reveals Conserved Epitopes for Broad-Spectrum Antivirals
Sashank Agrawal, Monika Jain, Daniella Marinelli, So Yeon Cho, Bryan S. Briney, Ian A. Wilson
This study determines the structure of HAstV spikes bound to FcRn, identifies conserved epitopes, and suggests repurposing FcRn inhibitors for antiviral therapy.
Cell Reports · Dec 1, 2025Peer-reviewedBiophysics