Capsinoids (non-pungent TRPV1 agonists) promote mild hypothermia and improved outcome following stroke in aged mice
Alexander P. Andersohn, Sodam Kim, Ting Wu, Andrea N. Doan, Charles Lowell Cantrell, Robert L. Jarret, Gab Seok Kim, Sean P. Marrelli
This study shows that capsinoids induce mild hypothermia in aged mice after stroke, reducing brain injury and improving survival and functional outcomes.
bioRxiv · Jun 10, 2026 · PreprintNeuroscience