Sean P. Marrelli

This study identifies stage-dependent changes in autonomic and neurotrophic signaling in alcohol-associated liver disease using bulk and single-cell transcriptomics.

This study shows that capsinoids induce mild hypothermia in aged mice after stroke, reducing brain injury and improving survival and functional outcomes.

This study examines chronic neurological changes after ischemic stroke in mice and humans, finding persistent inflammation, neuronal damage, and signs of accelerated aging in the brain.

This study shows that repeated mild head injury leads to senescence in cranial bone marrow, impairing brain metabolism and causing systemic inflammation.

This study identifies sex-specific metabolites in MCI patients through untargeted serum metabolomic profiling, revealing lipid pathway differences and potential biomarkers for AD.

This study shows that KRAS mutations drive brain arteriovenous malformations (bAVMs) in specific brain regions and that MEK inhibition can reduce their severity in mice, suggesting a potential therapeutic approach for human bAVMs.

This study identifies Slc4a4's role in maintaining blood-brain barrier integrity through the NO-CCL2-CCR2 pathway in astrocytes, showing its importance in both healthy and stroke conditions.

This paper describes a low-cost mouse cage warming system that improves temperature control during and after stroke experiments, reducing variability in outcomes.

This study shows that cortical stroke causes long-lasting gliosis in the ipsilateral thalamus, with memantine reducing gliosis at 2 weeks post-stroke.

The paper develops a novel Dll4 reporter allele to accurately monitor Dll4 expression in embryonic and adult mice, overcoming limitations of previous reporter lines.