Intraoperative glucocorticoids confound surgical biopsy transcriptomics
Frederik T. Larsen, Charlotte Wilhelmina Wernberg, Jyotsna Nambiar, Subhajit Dutta, Elise Jonasson Nielsen, Lea Ladegaard Grønkjær, Birgitte Gade Jacobsen, Susanne Mandrup, Anne Loft, Soeren Fisker Schmidt, Mette Munk Lauridsen, Kim Ravnskjær, Lars Grøntved
This study shows that intraoperative dexamethasone significantly alters hepatic gene expression in biopsy samples, confounding transcriptomic analyses of liver tissue.
JCI Insight · Oct 27, 2026Peer-reviewedGenetic & Genomic Medicine