Anne Loft

This study shows that intraoperative dexamethasone significantly alters hepatic gene expression in biopsy samples, confounding transcriptomic analyses of liver tissue.

This study identifies polyploid cardiomyocytes as disease-specific transcriptional states in the mammalian heart and suggests targeting them for heart failure treatment.

This study examines transcriptional changes in human adipose tissue during weight loss from lifestyle and bariatric surgery, showing significant remodeling and reduced inflammation.

The paper links adipose tissue cell states to progression and clinical subtypes of MASLD in human obesity using single-nucleus RNA sequencing and bulk RNA-seq data.

This study shows that loss of TLE3 enhances mitochondrial function in beige adipocytes, improves glucose metabolism, and prevents weight gain.