scPrediXcan integrates advances in deep learning and single-cell data into a powerful cell-type-specific transcriptome-wide association study framework
Yichao Zhou, Temidayo Adeluwa, Lisha Zhu, Sofia Salazar, Sarah Sumner, Hyunki Kim, Saideep Gona, Festus M. Nyasimi, Rohit N. Kulkarni, Joseph E. Powell, Ravi Madduri, Boxiang Liu, Mengjie Chen, Hae Kyung Im
scPrediXcan improves transcriptome-wide association studies by integrating deep learning for cell-type-specific gene expression prediction, identifying more causal genes and explaining more GWAS loci in type 2 diabetes and systemic lupus erythematosus.
bioRxiv · Nov 11, 2024 · PreprintGenetics