Hyunki Kim

FX-seq improves snRNA-seq from FFPE and PFA-fixed tissues by removing crosslinks and preventing RNA leakage, enabling analysis of 321,710 nuclei from mouse and human samples.

scPrediXcan improves transcriptome-wide association studies by integrating deep learning for cell-type-specific gene expression prediction, identifying more causal genes and explaining more GWAS loci in type 2 diabetes and systemic lupus erythematosus.

This study shows APOBEC3A, not APOBEC3B, causes significant mutagenesis in human gastric epithelium through whole-genome sequencing of organoids with inducible APOBEC3A or APOBEC3B.

The paper identifies pathogenic variants in Lynch Syndrome genes in patients with multiple cancers and finds higher prevalence of non-LS gene variants in early-onset cases.