So similar, yet so different: the paradigm of PARP9 macro domain paralogs
Nikolaos K. Fourkiotis, Christos Sideras‐Bisdekis, Aikaterini C. Tsika, Alexander Fish, Konstantina P. Kravvariti, Sofia-Antigoni Tsatsouli, Anastassis Perrakis A, Aleksandra Chikunova, Georgios A. Spyroulias
This study investigates the functional divergence between two macro domains in PARP9, showing how their distinct thermodynamics and ligand binding dynamics enable their roles as an eraser and a reader.
bioRxiv · Aug 17, 2026 · PreprintBiochemistry