Alexander Fish

SMIM1 drives an alternative iron uptake pathway

This study identifies SMIM1 as a key regulator of an alternative iron uptake pathway through hemoglobin binding and lysosomal iron release, with implications for iron homeostasis and erythropoiesis.

So similar, yet so different: the paradigm of PARP9 macro domain paralogs

This study investigates the functional divergence between two macro domains in PARP9, showing how their distinct thermodynamics and ligand binding dynamics enable their roles as an eraser and a reader.

Identification of allo- or orthosteric VHH/single-domain antibodies that enhance or block pathogen binding to Siglec-1 on dendritic cells

The paper identifies VHH/single-domain antibodies that either block or enhance Siglec-1 ligand binding to sialylated pathogens on dendritic cells.

USP1/UAF1 targets polyubiquitinated PCNA with an exo-cleavage mechanism that enriches for monoubiquitinated PCNA

This study shows USP1/UAF1 cleaves K48 and K63-linked ubiquitin chains on PCNA via exo-cleavage, preferentially enriching monoubiquitinated PCNA, which may influence DNA damage tolerance pathway choice.