Structural Characterization of Calcium-Dependent Calmodulin-Calmidazolium Binding using Capillary Vibrating Sharp-Edge Spray-based Native Mass Spectrometry and In-Droplet Hydrogen Deuterium Exchange Mass Spectrometry
Sohag Ahmed, Axel Woehrling, Peng Li, Stephen J. Valentine, Kevin C. Courtney
This study uses native mass spectrometry and hydrogen deuterium exchange to analyze calcium-dependent calmodulin-calmidazolium interactions, revealing ligand-induced conformational changes and binding affinity.
bioRxiv · Jun 17, 2026 · PreprintBiochemistry