THE HIV-1 SILENCER BCL11B/CTIP2 REGULATES THE TLR3-MEDIATED CELLULAR RESPONSE TO VIRAL INFECTIONS
Muhammad Kashif, Marco De Rovere, Solène Fenninger, Clémentine Wallet, Christian Schwartz, Olivier Rohr, Thomas Loustau
This study shows that BCL11B/CTIP2 regulates the TLR3-mediated cellular response to viral infections by inhibiting NEAT1 expression and dampening interferon production, thereby reinforcing HIV-1 latency.
bioRxiv · Jan 14, 2026 · PreprintMolecular Biology