NMR structures of small molecules bound to a model of an RNA CUG repeat expansion
Jonathan L. Chen, Amirhossein Taghavi, Alexander J. Frank, Matthew A. Fountain, Shruti Choudhary, Soma Roy, Jessica L. Childs‐Disney, Matthew David Disney
The paper reports NMR structures of small molecules bound to an RNA CUG repeat expansion motif, revealing binding interactions and conformational changes that inform drug design.
Bioorganic & Medicinal Chemistry Letters · Jun 22, 2024Peer-reviewedBiochemistry