Fexinidazole and Corallopyronin A target Wolbachia-infected sheath cells present in filarial nematodes
Laura Chappell, Ricardo Peguero, William R. Conner, Sommer Fowler, Brandon S. Cooper, Kenneth M. Pfarr, Achim M. Hoerauf, Sara Lustigman, Judy A. Sakanari, William Sullivan
This study identifies Wolbachia-infected sheath cells in filarial nematodes and shows that Fexinidazole and Corallopyronin A reduce Wolbachia clusters in these cells.
PLoS Pathogens · Sep 8, 2025Peer-reviewedPathology