Bone morphogenetic protein 4 reduces global H3K4me3 to inhibit proliferation and promote differentiation of human neural stem cells
Sonali Nayak, Benjamin J. Best, Emily T. Hayes, Ashorne Krithiesh Mahenthiran, Nitin R. Wadhwani, Barbara L. Mania-Farnell, Rintaro Hashizume, John A. Kessler, Charles David James, Tadanori Tomita, Guifa Xi
The paper shows BMP4 reduces H3K4me3 levels in human neural stem cells by downregulating SETD1A and WDR82, leading to decreased proliferation and increased differentiation.
bioRxiv · Jan 22, 2020 · PreprintNeuroscience