John A. Kessler

This study shows that BMP signaling enhances APOE4-induced lipid metabolic dysfunctions in astrocytes, leading to increased neuronal tau phosphorylation and reduced survival.

The paper identifies hPSC-derived astrocytic progenitors with gene expression profiles matching GBM subtypes and reveals molecular pathways associated with these progenitors.

This study shows TAZ and YAP have distinct roles in regulating astrocyte differentiation and NPC proliferation through different signaling pathways.

The paper identifies DISE, an RNA interference-mediated cell death mechanism, as correlated with neurotoxicity in Alzheimer's disease and aging, showing shifts in 6mer seed toxicity in different models.

The paper integrates GWAS data with functional genomic annotations of decidual stromal cells to identify loci and target genes associated with gestational duration and preterm birth.

The paper shows BMP4 reduces H3K4me3 levels in human neural stem cells by downregulating SETD1A and WDR82, leading to decreased proliferation and increased differentiation.