Restoration of tumor suppressor protein with enhanced activity using super-tRNAs to induce tumor regression
Bangyan Kong, Zhetao Zheng, Zeyuan Mi, Zhiyang Dou, Yuelin Yang, Yuxuan Shen, Liangzhen Dong, Jingru Lv, Ying Li, Qing Duo Liang, Songlin Tian, Jiayu Wang, Hua Qiao, Qing Xia
This paper demonstrates that engineered super-tRNAs can restore and enhance tumor suppressor protein function by overcoming nonsense mutations, leading to tumor regression in xenograft models.
bioRxiv · Mar 18, 2025 · PreprintBioengineering