A Binding Site for CVN293 Reveals a Mechanism for Allosteric Control of THIK-1 K2P Channel Gating
Matilda Devlin, Karin E. J. Rödström, Chaimae Benkerdagh, Sophia Ber, Nigel G. Ramsden, Molly Rowlett, Sonke Cordeiro, Mehtab S. Hayre, Peter Proks, Simon L. Newstead, Wojciech Kopeć, Thomas Baukrowitz, Marcus Schewe, Stephen J. Tucker
This study identifies the binding site of CVN293 on THIK-1 K2P channel and reveals its allosteric inhibition mechanism through cryoEM structures and functional validation.
bioRxiv · Oct 28, 2026 · PreprintBiophysics