Spatial patterns of APOBEC mutagenesis in the tumour microenvironment of Asian breast cancer
Zi-Ching Tan, Yang Wu, Zhen Wei Neo, Mai Chan Lau, Soo-Hwang Teo, Joe Poh Sheng YEONG, Siow-Wee Chang, Jia Wern Pan
This study investigates how APOBEC mutagenesis and A3B deletion affect immune activation in Asian breast cancer using spatial transcriptomics, finding that mitochondrial mutations and cGAS-STING pathway activation drive immune responses instead of neoantigens.
bioRxiv · Jan 2, 2026 · PreprintCancer Biology