Angiogenic Steroids Induce Pathologic Scarring in a Preclinical Swine Model Via Dysfunctional Extracellular Matrix Deposition.
Erik Reiche, Patrick R. Keller, Vance V. Soares, Calvin R. Schuster, Siti Rahmayanti, Jessica Mroueh, Vanessa Mroueh, Marie Billaud, Sophia Hu, Hunter Hoover‐Watson, Christine Guo Lian, Yu Tan, Joshua C. Doloff, Annie E. Newell‐Fugate, Devin Coon
This study shows testosterone increases fibrosis and scar strength in a swine model, suggesting androgenic steroids contribute to pathologic scarring through extracellular matrix changes.
The FASEB Journal · Mar 26, 2024Peer-reviewedSystems Biology