Joshua C. Doloff

This study identifies fibroblast-macrophage signaling as critical for biomaterial-induced tissue remodeling, revealing prolonged inflammation and novel cell types involved.

This paper identifies age-related impairment in systemic mRNA translation as a barrier to mRNA vaccine efficacy and develops an LNP formulation to restore transgene expression and T cell immunity in aged hosts.

This paper introduces a custom electromagnetic impactor device for creating consistent contusion spinal cord injuries in pigs, validated through mechanical modeling and histological confirmation.

The paper develops a nanofiber-hydrogel composite incorporating mRNA lipid nanoparticles to create a local immunostimulatory niche for cancer immunotherapy, showing enhanced immune responses with a single dose.

This study compares intrauterine fibrosis development and immune responses across mouse strains and induction methods to identify a more clinically relevant model.

This study shows testosterone increases fibrosis and scar strength in a swine model, suggesting androgenic steroids contribute to pathologic scarring through extracellular matrix changes.