Increased cocaine self-administration and prefrontal cortical dysregulation of glutamatergic and GABAergic signaling in a rat model for sensory processing sensitivity
Rick Hesen, Francesca Mottarlini, Lucia Caffino, Sophie Fennema, Susanna Parolaro, Cyprien G.J. Guerrin, Boris B. Quednow, Fabio Fumagalli, Michel M. M. Verheij, Judith Regina Homberg
This study shows that high SPS-like rats have increased cocaine self-administration and altered glutamatergic/GABAergic signaling in the prefrontal cortex, suggesting a risk factor for cocaine use disorder.
bioRxiv · Oct 28, 2025 · PreprintNeuroscience