Judith Regina Homberg

Resting state fMRI detects pathological functional brain connectivity in the Ndufs4 knockout mouse model of Leigh syndrome during the pre-symptomatic stage of the disease

The paper uses rs-fMRI to detect altered functional connectivity in Ndufs4 knockout mice during the pre-symptomatic stage of Leigh syndrome, finding increased connectivity in multiple brain regions and no effect of KH176 treatment.

Cognitive resilience despite metabolic dysfunction after adolescent-onset high-fat high-sucrose diet exposure in rats

This study shows that adolescent-onset high-fat high-sucrose diet in rats causes metabolic dysfunction but not detectable cognitive impairment after 10 weeks of exposure.

Unravelling the neurocognitive mechanisms underlying counterconditioning in humans

This study uses fMRI to compare counterconditioning and regular extinction in humans, finding distinct neural patterns and more persistent threat memory extinction with counterconditioning.

Increased cocaine self-administration and prefrontal cortical dysregulation of glutamatergic and GABAergic signaling in a rat model for sensory processing sensitivity

This study shows that high SPS-like rats have increased cocaine self-administration and altered glutamatergic/GABAergic signaling in the prefrontal cortex, suggesting a risk factor for cocaine use disorder.

Increased ambient temperature mitigates pathology in the Ndufs4-/- mouse model of Leigh Syndrome

This study shows that raising ambient temperature in Ndufs4-/- mice improves their health outcomes, including longer lifespan and reduced pathology.

Perfect imperfections: seeking molecular and cellular asymmetries in the mouse brain

The paper uses spatial transcriptomics to analyze left-right gene expression and cell type differences in mouse brain regions, finding transcriptional asymmetries but no significant cell type abundance differences.

Different Sensitivity to Ethanol and Sucrose in DAT and SERT Knockout Rats

This study compares reward sensitivity to ethanol and sucrose in DAT and SERT knockout rats, finding DAT deletions broadly impair both rewards while SERT deletions selectively affect sucrose.

The Neural Blueprint of Stress Susceptibility: Brain-wide neuronal activity associated with the consequences of stress

This study identifies brain activity patterns associated with stress susceptibility in mice, highlighting key regions and network interactions linked to PTSD-like symptoms.

Activation mapping in multi-center rat sensory-evoked functional MRI datasets using a unified pipeline.

The paper assesses consistency of rat fMRI results across 12 centers using a unified pipeline and identifies variability due to experimental differences.

The universe is asymmetric, the mouse brain too.

This study identifies hemispheric asymmetry in mouse brains, revealing species-specific patterns and differences from humans, with implications for autism research.

Sensory processing sensitivity is associated with neural synchrony and functional connectivity during threatening movies

This study examines how sensory processing sensitivity relates to neural synchrony and functional connectivity during threatening movie viewing.

Hippocampal trauma memory processing conveying susceptibility to traumatic stress

The paper investigates hippocampal memory processing differences in mice susceptible to PTSD-like symptoms following trauma exposure.

TPH2 knockout male rats are aggressive, show less anxiety, and exhibit an altered oxytocin system

This study examines TPH2 knockout male rats, finding reduced anxiety, increased aggression, and altered oxytocin system function.

Knockout of the serotonin transporter in the rat mildly modulates decisional anhedonia

This study investigates the effect of serotonin transporter gene knockout on decisional anhedonia in rats, finding mild modulation that interacts with learning.

Serotonin transporter knockout in rats modulates category learning

This study uses a rat model to show that serotonin transporter knockout reduces learning rate and increases exploitation strategy in category learning, suggesting a link to repetitive behaviors in ASD.

Aberrant ventral dentate gyrus structure and function in individuals susceptible to post-traumatic stress disorder

The paper investigates structural and functional differences in the ventral dentate gyrus of mice susceptible to PTSD-like symptoms following trauma, identifying specific neuronal and synaptic changes associated with susceptibility.

Serotonergic development of active sensing

This study shows that altered serotonergic signaling during early postnatal development impairs adult sensorimotor control in rats.

Action of cocaine involves depletion of dopaminergic and serotonergic storage vesicles

This study shows cocaine increases extracellular dopamine and serotonin by depleting storage vesicles in the rat nucleus accumbens, with individual differences in vesicular release affecting behavior and drug intake.