Seesaw protein: Design of a protein that adopts interconvertible alternative functional conformations.
Toma Ikeda, Tatsuya Nojima, Souma Yamamoto, Ryusei Yamada, Tatsuya Niwa, Hiroki Konno, Hideki Taguchi
This paper designs a protein that can switch between two functional conformations, showing that such behavior can be controlled by mutations and ligands.
Proceedings of the National Academy of Sciences · Feb 10, 2025Peer-reviewedBiochemistry