Hideki Taguchi

YfiM is a lipid-linked oligosaccharide pyrophosphatase

The paper identifies YfiM and AT1G15900 as LLO pyrophosphatases in E. coli and Arabidopsis, revealing a conserved quality control mechanism across prokaryotes and plants.

Assembly-pathway regulation dictates pH-responsive actuation in the R-body protein machinery

This study identifies that assembly-pathway regulation, not just major components, dictates pH-responsive actuation in R-bodies by forming the ordered lamellar architecture required for function.

Structural insights into YheS-mediated release of SecM-arrested ribosome.

The paper elucidates the mechanism by which YheS releases SecM-arrested ribosomes using cryo-EM and molecular dynamics simulations.

Local aromatic interactions define temperature sensitivity of phase separation in an intrinsically disordered protein.

The paper investigates how temperature sensitivity in phase separation of an intrinsically disordered protein is encoded by local aromatic interactions, showing that tyrosine residues mediate both structural stability and phase behavior.

Mechanism of ATXN8OS CTA/CTG repeat-associated non-AUG translation revealed by approaches ranging from cell-free translation to live-cell imaging.

This study identifies the mechanism of ATXN8OS CTA/CTG repeat-associated non-AUG translation through cell-free systems and live-cell imaging, revealing frameshifting and stress response involvement.

Canonical translation factors eIF1A and eIF5B modulate the initiation step of repeat-associated non-AUG translation.

The paper identifies eIF1A and eIF5B as repressors of C9orf72-mediated RAN translation by showing their omission enhances RAN translation in all reading frames.

Pronounced expression of extracellular matrix proteoglycans regulated by Wnt pathway underlies the parallel evolution of lip hypertrophy in East African cichlids

The study identifies shared molecular mechanisms in hypertrophied lips of East African cichlids, linking Wnt pathway activation and extracellular matrix proteoglycan expression across different species.

Seesaw protein: Design of a protein that adopts interconvertible alternative functional conformations.

This paper designs a protein that can switch between two functional conformations, showing that such behavior can be controlled by mutations and ligands.

A newly-identified mini-hairpin shaped nascent peptide blocks translation termination by a novel mechanism.

The paper identifies two novel ribosome arrest peptides in E. coli and elucidates their unique mechanism of translation arrest.

The Escherichia coli small heat shock protein IbpA plays a role in regulating the heat shock response by controlling the translation of σ32

The paper identifies IbpA as a regulator of the heat shock response in E. coli by suppressing σ32 translation, contributing to the shutdown of the response.

FUS regulates RAN translation through modulating the G-quadruplex structure of GGGGCC repeat RNA in C9orf72-linked ALS/FTD

This study shows FUS suppresses RAN translation by modulating G-quadruplex structure of GGGGCC repeat RNA, reducing neurodegeneration in C9-ALS/FTD model flies.

Novel trans-translation-associated gene regulation revealed by prophage excision-triggered switching of ribosome rescue pathway

The paper shows that prophage excision in E. coli inactivates SsrA RNA, switching ribosome rescue from trans-translation to ArfA/RF2, and reveals a regulatory mechanism involving nonstop mRNA translation and ZntR repression.