Disruption of GABA-Regulated Network Resilience in Human Cerebral Organoids Leads to Fragmented Small-World States and Reduced Connectivity
Sriram Ayalavarapu, Natalie Smith, Zane R. Lybrand
This study shows that mechanical stress disrupts network resilience in human cerebral organoids, increasing fragmentation and reducing connectivity, with GABAergic signaling playing a critical role in recovery.
bioRxiv · Jun 11, 2025 · PreprintNeuroscience