Zane R. Lybrand

This study shows that mechanical stress disrupts network resilience in human cerebral organoids, increasing fragmentation and reducing connectivity, with GABAergic signaling playing a critical role in recovery.

This study investigates the effects of ARX poly-alanine mutations in human brain organoids, revealing altered interneuron migration and cortical neuron development.

The paper shows that a small number of dysregulated adult-born neurons in the hippocampus disrupt brain-wide functional connectivity and spatial memory.