DNA-Dependent Protein Kinase Inhibitors PI-103 and Samotolisib Augment CRISPR/Cas9 Knockin Efficiency in Human T Cells
Emina Džafo, Morteza Hafezi, Greta Maria Paola Giordano Attianese, Patrick Reichenbach, Stéphane Grillet, Hélène Garcia, Elisabetta Cribioli, Christel Voize, Stéphanie Tissot-Renaud, Romain Vuillefroy de Silly, George Coukos, Kirsten B. J. Scholten, Melita B. Irving, Bernhard Gentner
This study shows that PI-103 and samotolisib enhance CRISPR/Cas9-mediated TCR knockin efficiency in human T cells without affecting viability or phenotype.
Cytotherapy · Feb 10, 2025Peer-reviewedBioengineering